About Us

At the Center for Translational NeuroImaging (CTNI), we focus on three vital research areas:

Neurodegeneration

The CTNI’s work on neurodegenerative diseases unravels the mechanisms behind conditions like Alzheimer’s disease (marked by amyloid-beta plaques and tau tangles), Parkinson’s disease, and ALS. Through cutting-edge MRI techniques, we visualize the progression of these diseases at a molecular level. Research also includes the study of Chronic Traumatic Encephalopathy (CTE), a disease often linked to repeated brain trauma, furthering our understanding of how neurodegeneration is triggered and progresses. By identifying early biomarkers and pathways of degeneration, CTNI seeks to inform the development of novel treatments and a more holistic understanding of the neurobiological mechanisms of disease progression.

Drug Abuse

We are at the forefront of studying the effects of various drugs on the brain. From schedule 1 substances like psychedelics and cannabis, to widely-used medications like Methamphetamines, we explore how these drugs alter brain chemistry, function, and neuroplasticity. This includes understanding both their therapeutic potential—especially in the case of psychedelics for mental health treatment—and the risks of addiction or cognitive impairment. Our research looks into how long-term or recreational use can affect the brain’s reward system and behavior, contributing to both clinical interventions and public health policy on drug use.

Repetitive Mild Traumatic Brain Injuries (rmTBI)

The CTNI investigates how repetitive head trauma, such as sports-related concussions, affect the brain’s structure and function. Research aims to understand the cumulative effects of rmTBI and how it leads to long-term brain damage. This includes exploring links to Chronic Traumatic Encephalopathy (CTE), a condition commonly observed in athletes and military personnel. Using advanced MRI, the lab visualizes changes in brain tissue over time to identify early markers of damage. Through this work, we aim to develop preventive strategies and targeted therapies to mitigate the impact of repeated head injuries on neurocognitive health.